Self-Learning AI Releases NFL Picks: Bills 38-28 Over Jets
SportsLine's AI has published predictions for every NFL Week 10 game, projecting a 38-28 Bills win over the Jets. Four teams are on byes, and winless Chargers visit Ravens on Monday night as Jacoby Brissett expected to make his Baltimore debut.
SportsLine's self-learning AI releases NFL picks and score predictions for every Week 10 game, projecting the Buffalo Bills to beat the New York Jets 38-28. The system also leans toward the over on the 51-point total and likes Buffalo at -8.5 against the spread.
Byes and divisional games
Four teams have the week off: the Bears, Broncos, Eagles and Buccaneers. Several divisional games fill the Sunday slate despite that.
The lines listed include Panthers vs. Saints (-2.5), Jaguars vs. Titans (+10.5), Vikings vs. Packers (-3.5), Rams vs. Cardinals (+9.5) and Steelers vs. Bengals (-3.5). That last game is the 'Sunday Night Football' fixture. Texans vs. Browns (+5.5), Dolphins vs. Colts (-3.5) and 49ers vs. Cowboys (+3.5) are the conference matchups.
On 'Monday Night Football,' the winless Los Angeles Chargers visit the Baltimore Ravens (-4.5). Newly acquired quarterback Jacoby Brissett is expected to make his Baltimore debut.
Why the model likes Buffalo
The Bills lead the AFC East this season after finishing second a year ago. The Jets are 2-7, third in the division, and have lost four straight.
Buffalo has won each of the last five meetings, including two wins by 20-plus points in 2025. Quarterback Josh Allen, the 2024 NFL MVP, completed 21 of 34 passes for 289 yards and two touchdowns, with one interception, in a 36-10 win over Baltimore on Nov. 1.
Last season Allen completed 69.3% of his passes for 3,668 yards and 25 touchdowns over 17 games. He threw 10 interceptions.
Jets' numbers
Veteran quarterback Geno Smith has completed 67.5% of his passes for 2,078 yards and 12 touchdowns in nine games. He has thrown three interceptions and carries a 100.5 passer rating.
Running back Braelon Allen has 120 carries for 598 yards, a 5.0-yard average, and three touchdowns. He also has 19 receptions for 102 yards.
How the AI works
SportsLine says its Data Science team built the AI predictions and ratings using machine learning. The model learns from each team's historical data, then scores the strength of the opposing defense with a matchup score out of 100.
SportsLine says the system refreshes continuously on the latest data and can flag gaps between its numbers and the lines at betting sites. It says the AI has hit more than 2,000 highly rated picks since the start of the 2023 season.
Those track-record claims come from SportsLine and are not independently verified. The full Week 10 predictions sit behind SportsLine's site.
